Can long-range microsatellite data be used to predict short-range linkage disequilibrium?
نویسندگان
چکیده
منابع مشابه
Long-Range Linkage Disequilibrium in the Human Genome
In the study of genomic variation, the nonrandom association of alleles has been a valuable tool for understanding population history, correlating disease phenotypes, and mapping genetic structural variation. These associations, termed linkage disequilibrium, have been quantified to great extent in humans over short distances. Linkage disequilibrium between genetically distant sites has garnere...
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Long-range linkage disequilibria (LRLD) between sites that are widely separated on chromosomes may suggest that population admixture, epistatic selection, or other evolutionary forces are at work. We quantified patterns of LRLD on a chromosome-wide level in the YRI population of the HapMap dataset of single nucleotide polymorphisms (SNPs). We calculated the disequilibrium between all pairs of S...
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ژورنال
عنوان ژورنال: Human Molecular Genetics
سال: 2002
ISSN: 1460-2083
DOI: 10.1093/hmg/11.12.1363